Effects of endocrine active substances

Research group of Ilka Lutz
An example of how the cellular morphology of a thyroid gland can be affected by a thyroid-active substance. Upper row left and right: histological picture of a normal thyroid gland of the African clawed frog (X. laevis). Lower row left and right: histological modification of thyroid cells (magnification 50 and 200 µm). | Images: Claudia Lorenz

An example of how the cellular morphology of a thyroid gland can be affected by a thyroid-active substance. Upper row left and right: histological picture of a normal thyroid gland of the African clawed frog (X. laevis). Lower row left and right: histological modification of thyroid cells (magnification 50 and 200 µm). | Images: Claudia Lorenz

In our working group we investigate the effects of environmentally relevant compounds on different hormone systems of aquatic vertebrates. Hormones regulate various physiological processes, e.g. development, growth and reproduction in all vertebrates. One focus of our work is the investigation of effects on the thyroid system, which is essential for the normal development in all vertebrates. Since early developmental stages are most sensitive to harmful influences by the environment, we analyse effects of chronical or acute exposures to environmental substances in larvae of Cyprinus carpio (Carp) and Xenopus laevis (South African clawed frog). In doing so, we evaluate modifications of the larvae morphology, gene expression of key factors and whether thyroid morphology is affected. With our research we aim to contribute to show possible effects of environmentally relevant chemicals on the physiology of aquatic wildlife.

Group members

Ilka Lutz

Research group leader
Working group
Effects of endocrine active substances

Antje Tillack

Technician/Lab operator
Working group
Effects of endocrine active substances

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